Chiefs vs. Chiefs Prediction 49ers: odds, expert picks, QB matchup, injury report, betting trends and stats

The Kansas City Chiefs will face the San Francisco 49ers this Sunday at 4:25 pm ET at Levi’s Stadium. Both teams could not have started the season any differently. The Chiefs are 5-0 while the 49ers are 3-3.

Despite the differences in their records, the two teams have a striking similarity. Both are full of injuries. For the Chiefs, they have already lost Isiah Pacheco and Rashee Rice to IR and WR Hollywood Brown has yet to see the field.

The most significant injury the 49ers have faced so far this season comes to last year’s Offensive Player of the Year, Christian McCaffery.

These two teams last met in the Super Bowl in 2020, where the Chiefs emerged victorious. Historically, this matchup has been very close, with the Chiefs holding a 6-5 edge over the 49ers.

NBC Sports offers the latest information and analysis, including how to tune in to kickoff, DraftKings odds, player news and updates, as well as expert predictions and best bets for the game.

Listen to the Bet the Edge podcast as hosts Jay Croucher and Drew Dinsick provide listeners with practical and accurate insights, market analysis and statistical data to help bettors gain more information before placing their bets.

Game details and how to watch Kansas City Chiefs @ San Francisco 49ers live on Sunday afternoon

· Date: Sunday, October 20, 2024
· Time: 4:25 p.m. ET
· Website: Levi’s Stadium
· City: Santa Clara, California
· TV/broadcast: FOX

Want to check out the other games on NFL Schedule this week? We’ve got you covered right here at NBC Sports with all the matchups, location, game time and TV/streaming information so you don’t miss any of the action!

Latest Game Odds for Kansas City Chiefs @ San Francisco 49ers

The latest odds as of Saturday morning, courtesy of DraftKings:

· Money Line: Kansas City Chiefs (+105), San Francisco 49ers (-125)
· To spread: 49ers -2
· Total: 47

Given the Chief’s injuries, the line opened as a pick ’em, but it changed in the 49ers’ favor.

Be sure to check out DraftKings for the latest game odds and player props for every matchup this week!

NBC Sports Bet Best Bets

NBC sports betting analyst Brad Thomas (@MrBradThomas) has his eye on the 49ers -2:
“The 49ers have the advantage of playing at home against a badly damaged Chiefs team. With the Chiefs coming into this game 5-0, it’s a great selling point for sports bettors.”

Kansas City Chiefs @ San Francisco 49ers, Team Stats & Betting Trends

· The Chiefs have covered 15 of their last 18 as road underdogs.
· The 49ers are 3-7 against the spread in their last 10 games.
· The Chiefs have won the last five games as underdogs.
· The 49ers are 12-6 in their last 18 games.

Quarterback matchup for Kansas City Chiefs vs. San Francisco 49ers

· Bosses: Patrick Mahomes threw for 1,2355 yards, 6 TDs and 6 INTs.
· 49ers: Brock Purdy threw for 1,629 yards, 9 TDs and 4 INTs.

Kansas City and San Francisco Player News and Injuries

Bosses:
WR JuJu Smith-Schuster (hamstring) is questionable
WR Hollywood Brown (shoulder) is on IR
WR Rashee Rice (knee) is on IR
RB Isiah Pacheco (fibula) is on IR

49ers:
WR Ricky Pearsall (chest) is on NF-IR
the K Matthew Right (shoulder) is questionable
WR Deebo Samuel Sr. (calf) is questionable
RB Jordan Mason (shoulder) is questionable
Christian McCaffery (calf/Achilles tendon) is on IR

Rotoworld still offers all the latest news NFL betting information and tools with game predictions, player suggestions, futures and trends!

Expert Picks & Predictions for Kansas City @ San Francisco

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Our model calculates projections around every money line, spread and over/under bet for every game on the NFL schedule based on data points like past performance, player matchups and weather forecasts.

After running the model, we place its projection close to the last betting lines so that the game reaches a relative confidence level for each bet.

Here are the best bets our model is projecting for Chiefs @ 49ers:

· Money Line: NBC Sports Is Avoiding a Moneyline Play
· To spread: NBC Sports is leaning toward playing the Chiefs against the spread
· Game total: NBC Sports is leaning slightly toward a play at Total OVER 47.5 points.

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