Chargers vs. Cardinals Prediction: Odds, Expert Picks, QB Matchup, Injury Update, Betting Trends & Stats

Looking to build momentum after last week’s impressive win over the Broncos, the Chargers (3-2) travel to Glendale, Arizona, on Monday night for a game against the struggling Cardinals (2-4).

Coach Harbaugh’s mantra of “play good defense and hit the rock” is taking hold in SoCal. The defense is surrendering 13.2 points per game, the minimum in the NFL. The offense is led by JK Dobbins, who is averaging 5.4 yards per carry this season. The team as a whole occupies 10th position^the in the NFL in rushing and with tackles Rashawn Slater and Joe Alt expected to play on Sunday, the Chargers hope to control the line of scrimmage and hope to pull off another 20-play, 10-minute plays like they did last weekend against the Broncos.

Arizona’s defense was expected to be somewhat porous this season… and they rank 29th^the in the NFL stopping the run. To combat the weakness, the Cardinals need QB Kyler Murray to move the ball with his arms and legs. He has been erratic and inconsistent this season, but he led Arizona to a victory over San Francisco. He will need to be this good again on Monday.

Let’s dive into the showdown and find a hoodie or two.

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Game details and how to watch Chargers @ Cardinals

• Date: Monday, October 21, 2024
• Time: 9pm EST
• Location: State Farm Stadium
• City: Glendale, AZ
• TV/streaming: ESPN+

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Game Odds for Chargers @ Cardinals

The latest Saturday odds, courtesy of DraftKings:

• Money Line: Los Angeles Chargers (-122), Arizona Cardinals (+102)
• To spread: Chargers -1.5
• Total: 44

The Chargers opened with a 2.5 lead, so there is money coming in for the Cardinals. Total is currently where it opened at 44.

NBC Sports Bet Best Bets

NBC sports betting analyst Drew Dinsick (@whale_capper) likes to play Total on this game:
“There’s no disagreement with the Chargers being favored here, but I don’t think the market understands why they should be the favorite. I think the Chargers offense is underrated right now, facing a very weak Cardinals unit overall. And I think the Chargers defense is overrated. So my fair price on this Total would be 46. Give me MORE than 43.5. In fact, it’s the biggest play of the week for me at Total.

Chargers @ Cardinals Betting Trends & Stats

• The Chargers are 4-1 ATS in their last five games as road favorites.
• The Cardinals have lost seven of their last ten games.
• UNDER is 4-1 in the Chargers’ last five games.
• Kyler Murray has thrown 1 or fewer TDs in 11 of his last 14 games.
• Rookie WR Marvin Harrison Jr. (concussion) is expected to play Monday. He leads the Cards with 279 receiving yards and 4 TDs.
• The Chargers have won 5 of the last 6 meetings in this series.

Quarterback matchup for Chargers @ Cardinals

• Los Angeles: Justin Herbert – last Sunday the veteran threw 237 yards in the victory over Denver. It was the 1^st Once in 5 games he threw for over 180 yards.
• Arizona: Kyler Murray – In last week’s loss at Green Bay, Murray threw for just 214 yards and ran for just 14.

Chargers and Cardinals injury updates

· LA WR Ladd McConkey (hip) is questionable for Monday’s game.
· LA CB Deane Leonard (hamstring) was ruled out of Monday’s game.
· LA TE Hayden Hurst (groin) is doubtful for Monday’s game.
· LA LB Joey Bosa (hip) is doubtful for Monday’s game.
· Arizona LB Owen Pappoe (undisclosed) has been ruled out of Monday’s game.
· Arizona RB Trey Benson (illness) is questionable for Monday’s game.
· Arizona MLB Kyzir White (knee) was limited in Saturday’s practice and is questionable for Monday’s game.

Expert Picks & Predictions for Chargers @ Cardinals

Please bet responsibly. If you or someone you know has a gambling problem, call the National Gambling Helpline at 1-800-522-4700.

Our model calculates projections around every money line, spread and over/under bet for every game on the NFL schedule based on data points like past performance, player matchups, betting trends and weather forecasts.

After running the model, we place its projection close to the last betting lines so that the game reaches a relative confidence level for each bet.

Here are the best bets our model is projecting for Monday’s game between Los Angeles and Arizona:

· money line: NBC Sports Is Leaning to Play the Chargers on the Moneyline
· To spread: NBC Sports is staying away from a play on the spread
· Total: NBC Sports Is Leaning to Play Total UNDER 44

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